Before incorporating hyaluronidase into clinical practice, it is crucial to fully understand its mechanisms of action, indications, and limitations. This e-book is a practical guide for physicians, presenting current knowledge on the enzymatic degradation of hyaluronic acid, therapeutic protocols, and safety. It includes a discussion of hyaluronidase pharmacodynamics and pharmacokinetics, dosing guidelines for various clinical situations, algorithms for managing filler-related complications, and the latest recommendations based on evidence-based medicine. The publication also includes an analysis of potential adverse reactions, the risk of anaphylaxis, and the elements necessary for proper patient qualification and medical record keeping.